A distinct tau oligomer strain defines the molecular and proteomic landscape of rapidly progressive Alzheimer's disease - PubMed
5 hours ago
- #Proteomics
- #Tau oligomers
- #Alzheimer’s disease
- A distinct tau oligomer strain defines rapidly progressive Alzheimer's disease (rpAD).
- rpAD exhibits compact, densely packed tau oligomers with high phosphorylation levels.
- Tau oligomers from rpAD and slowly progressive AD (spAD) reduce SH-SY5Y cell viability.
- Proteomic profiling identifies 2388 TauO-associated proteins, with rpAD showing unique interactors.
- rpAD TauO interactome is enriched in metabolic and cytoskeletal pathways, differing from spAD and controls.
- Findings suggest rpAD has a biochemically distinct TauO species linked to its aggressive clinical course.