Spi-1 proto-oncogene regulates mRNA hypertranscription and malignant progression in head and neck cancer - PubMed
7 hours ago
- #SPI1
- #hypertranscription
- #HNSCC
- Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal cancer with poor long-term survival.
- Hypertranscription, a genome-wide increase in RNA output, is a hallmark of oncogenic transformation.
- Elevated mRNA hypertranscription in HNSCC is linked to oncogenic pathway activation and poor clinical outcomes.
- The transcription factor Spi-1 Proto-Oncogene (SPI1) regulates mRNA hypertranscription in HNSCC malignant cells.
- SPI1 drives cell proliferation, invasion, migration, and tumor growth in vitro and in vivo.
- SPI1 overexpression increases nascent RNA synthesis and targets oncogenic transcriptional programs.
- SPI1-driven mRNA hypertranscription plays a key role in HNSCC progression.