Altered Cytokine-Induced STAT3 and STAT5 Activation of Peripheral T Follicular Helper Cells Contributes to Vaccine-Non-Responsiveness in Aging and HIV - PubMed
2 days ago
- #STAT Signaling
- #HIV and Vaccination
- #Aging and Immunity
- Functional defects in peripheral T follicular helper cells (pTfh) contribute to non-responsiveness to influenza vaccine in aging and HIV.
- Study investigates IL-21-induced STAT3 and IL-2-induced STAT5 activation in pTfh cells affecting vaccine responses in aging people with and without HIV.
- Participants included young and old individuals with and without HIV, classified as vaccine responders (VR) or non-responders (VNR) based on antibody titers.
- Young individuals showed greater IL-21-induced STAT3 and reduced IL-2-induced STAT5 activity in pTfh cells compared to older individuals.
- IL-2-induced STAT5 in pTfh cells inversely correlated with vaccine titers in non-responders.
- Aging increases IL-2-induced STAT5 signaling in pTfh, potentially hindering Tfh cell differentiation and function, leading to weaker vaccine responses.