Metabolic and inflammatory roles of glial cells in neurodegenerative and cerebrovascular diseases - PubMed
6 hours ago
- #glial cells
- #neuroinflammation
- #therapeutic targets
- Chronic neuroinflammation, driven by microglia and astrocytes, is central to neurodegenerative and cerebrovascular diseases.
- Single-cell studies show glial heterogeneity; microglia shift to glycolysis, releasing cytokines and ROS, while astrocytes accumulate toxic lipids, amplifying inflammation.
- Key pathways like NF-κB, NLRP3, and C3/C3aR foster glial activation and detrimental feedback loops, worsened by cholesterol issues, vesicle communication, and mitochondrial dysfunction.
- The review highlights gaps in understanding context-specific interactions and discusses treatments targeting glial metabolism and immune signaling to slow disease progression.