SIRT1 enhances alveolar bone repair by regulating glycolytic metabolism via the Wnt/β-catenin pathway - PubMed
5 hours ago
- #Alveolar Bone Repair
- #Wnt/β-catenin Pathway
- #Glycolytic Metabolism
- SIRT1 is crucial for alveolar bone repair post-extraction.
- Its deletion in mice (Wnt1-Cre; SIRT1fl/fl) impairs bone healing and reduces glycolysis in orofacial mesenchymal stem cells.
- SIRT1 interacts with β-catenin; deficiency leads to increased β-catenin acetylation and reduced nuclear localization.
- This disrupts Wnt/β-catenin signaling and glycolytic metabolism, hindering osteogenesis.
- Activating Wnt signaling with agonist SKL2001 rescues β-catenin translocation, glycolysis, and bone repair.