Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor - PubMed
14 hours ago
- #Marburgvirus
- #Glycoprotein
- #NPC1 receptor
- Marburgvirus (MBV) glycoprotein (GP) mediates viral entry more efficiently than Ebola virus (EBOV) GP.
- Cryo-EM structures of MBV GP were determined in three states: unbound, bound to NPC1 receptor, and complexed with a neutralizing nanobody.
- The glycan cap shields the receptor-binding site from NPC1 but only partially from the nanobody, enabling limited immune evasion.
- NPC1 binds to MBV GP in a distinct orientation compared with EBOV GP, enhancing receptor affinity and facilitating membrane fusion.
- MBV GP is susceptible to a neutralizing nanobody that mimics NPC1 at the receptor-binding site.
- The findings suggest structural mechanisms contributing to MBV GP's enhanced entry efficiency.