Integrative GWAS identifies novel loci and genetic links between psychiatric and metabolic factors in anorexia nervosa - PubMed
21 hours ago
- #Psychiatric-Metabolic Interplay
- #GWAS
- #Anorexia Nervosa
- Novel genome-wide significant locus near the SOX5 gene identified through meta-analysis of AN GWAS data from European and Finnish populations.
- Genetic correlation and Mendelian randomization analyses reveal shared and potentially causal relationships between AN and psychiatric/metabolic traits.
- Local genetic correlation analysis identified 185 significant genomic regions, with 100 showing pleiotropic effects across multiple traits.
- MTAG analyses identified 86 significant loci, including 25 novel ones such as VAMP2, LPL, and BDNF.
- Gene Co-expression Network Analysis highlights key modules linked to synaptic signaling and lipid metabolism pathways.
- Single-cell transcriptomic analysis shows genetic risk concentrated in limbic and striatal GABAergic neurons and extends to cortical motor regions.
- Findings demonstrate intricate genetic interplay between psychiatric and metabolic pathways in AN, emphasizing the need for an integrated approach.