Safety and efficacy of decompressive craniectomy versus standard craniotomy for large acute epidural haematoma with tentorial herniation in China (PREDICT-AEDH): a nationwide, multicentre, open-label,
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- #Epidural Haematoma
- #Randomized Controlled Trial
- #Decompressive Craniectomy
- The PREDICT-AEDH trial compared decompressive craniectomy to standard craniotomy for large acute epidural haematoma with tentorial herniation.
- At 6 months, no significant difference was found in functional outcomes (GOSE ≥5: 79% vs 84%).
- Decompressive craniectomy increased the risk of delayed intracranial haemorrhage compared to craniotomy (36% vs 13%).
- Safety outcomes like 30-day mortality and postoperative cerebral infarction were similar between groups.
- The study does not support routine prophylactic decompressive craniectomy in this patient population.