Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state - PubMed
5 hours ago
- #fibroblasts
- #cancer
- #gene-editing
- Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast (CAF) state.
- Knocking out receptors Osmr, Tgfbr2, or Il1r1 on CAFs shows TGFBR2 signaling loss induces a Col18a1hi CAF state linked to worse survival in pancreatic cancer.
- Col18a1hi CAFs recruit Siglec-Fhi neutrophils via Cxcl5 expression and depend on TNFR1 and canonical Wnt signaling.
- A fast, affordable, and modular gene editing method helps discover modified fibroblast identities and local intercellular relationships in the tumor microenvironment (TME).