Unraveling the Link Between Azathioprine and Acute Pancreatitis: Integrating Network Toxicology, Machine Learning, and Mendelian Randomization - PubMed
2 months ago
- #machine-learning
- #acute-pancreatitis
- #azathioprine
- Azathioprine (AZA) is linked to acute pancreatitis (AP), but the molecular mechanisms are unclear.
- The study used network toxicology, machine learning, Mendelian randomization (MR), and molecular docking to explore AZA-induced AP.
- 68 candidate genes related to AZA-induced AP were identified, involving lipid metabolism, inflammation, and energy homeostasis.
- Machine learning highlighted seven key genes (CES1, CTSK, JAK1, NR3C2, PLIN5, WEE1, RORA) central to AP development.
- MR analysis showed decreased expression of CES1 and CTSK may increase susceptibility to AZA-related AP.
- Molecular docking revealed strong binding between AZA and CES1/CTSK proteins.
- CES1 and CTSK are identified as protective factors and mechanistic mediators in AZA-triggered AP.