ZEB1 maintains mitochondrial fission and macrophage efferocytosis by restraining MFN2, thereby limiting inflammation and improving tendon‑bone healing - PubMed
5 hours ago
- #tendon-bone healing
- #efferocytosis
- #ZEB1
- ZEB1 plays a crucial role in maintaining mitochondrial fission and macrophage efferocytosis by inhibiting MFN2.
- ZEB1 deficiency leads to excessive mitochondrial fusion, reduced apoptotic cell clearance, and an aggravated inflammatory microenvironment.
- In vivo studies show that ZEB1 knockdown results in accumulation of necrotic cells, increased M1 and decreased M2 macrophage polarization, impairing tendon-bone healing.
- The ZEB1/MFN2/mitochondrial fission axis is identified as a key regulator of macrophage efferocytosis and inflammation resolution.
- Targeting the ZEB1/MFN2 axis presents a potential therapeutic strategy for improving tendon-bone healing by restoring the immune microenvironment.