Cumulative inflammatory index and the risk of cardiometabolic multimorbidity: a prospective cohort study among middle-aged and older adults in China - PubMed
6 hours ago
- #inflammation
- #prospective cohort study
- #cardiometabolic multimorbidity
- Study examines the link between cumulative inflammatory indices and cardiometabolic multimorbidity (CMM) in middle-aged and older adults in China.
- Six cumulative inflammatory indices were evaluated, with cumCRP, cumWBC, cumCRP/HDL, and cumulative inflammatory score showing positive associations with CMM risk.
- cumHDL exhibited a negative linear relationship with CMM outcomes.
- cumCTI (C-reactive protein-triglyceride-glucose index) showed the strongest association with CMM incidence, with a hazard ratio (HR) of 2.19.
- External validation using the ELSA database confirmed cumCTI as the strongest predictor of CMM incidence, with an AUC of 0.75 and HR of 3.28.
- The study highlights the importance of long-term monitoring of CTI fluctuations for early prevention and mitigation of CMM.