Integration of plasma eMTBR-tau243 and p-tau217 in the diagnosis and stratification of Alzheimer's disease: a prospective cohort study - PubMed
5 hours ago
- #Alzheimer's disease
- #Biomarkers
- #Cognitive decline
- Plasma p-tau217 and eMTBR-tau243 biomarkers improve Alzheimer's disease diagnosis and stratification.
- Study involved 572 patients with cognitive symptoms, showing 51% were female and 49% male.
- Plasma p-tau217 confirmed Aβ-positivity in 61% of patients, with 57% having established Alzheimer's disease.
- eMTBR-tau243 improved classification accuracy to 81% for established Alzheimer's disease.
- Combined use of p-tau217 and eMTBR-tau243 enhances assessment of Alzheimer's pathology and symptom causation.
- eMTBR-tau243 also predicts cognitive decline and tau tangle accumulation, aiding therapeutic decisions.
- Findings validated in an independent cohort, supporting the biomarkers' reliability.
- Funding from multiple national and international sources underscores the study's significance.