Association of nasopharyngeal Dolosigranulum pigrum and Corynebacterium species with post-acute sequelae of SARS-CoV-2 in a longitudinal cohort - PubMed
5 hours ago
- #Microbiome
- #PASC
- #COVID-19
- Longitudinal study on nasopharyngeal microbiome in COVID-19 patients and its link to post-acute sequelae (PASC).
- Microbiome analysis included healthy participants, influenza patients, and moderate/severe COVID-19 cases.
- No significant differences in overall microbiome diversity between groups, but specific species like Dolosigranulum pigrum and Corynebacterium were linked to PASC.
- Lower abundance of D. pigrum and Corynebacterium species in patients who developed PASC, suggesting a protective role.
- Antibiotic use associated with reduced levels of protective taxa, potentially increasing PASC risk.
- Findings suggest microbiome balance is crucial for recovery and may inform future probiotic or metabolite-based treatments.