Lidocaine combined with low-dose esketamine for movement-evoked pain after hepatectomy: a double-blind randomised controlled trial - PubMed
6 hours ago
- #Esketamine
- #Lidocaine
- #Hepatectomy Pain
- Lidocaine combined with low-dose esketamine reduced movement-evoked pain scores at 24, 48, and 72 hours after hepatectomy compared to placebo.
- Moderate-to-severe movement-evoked pain at 24 hours was lower in the lidocaine-esketamine group (34% vs. 56% with placebo, p<0.001).
- Cumulative opioid (sufentanil) consumption was significantly reduced and quality of recovery scores were higher in the lidocaine-esketamine group up to 72 hours post-surgery.
- The improvements in pain, opioid use, and recovery with lidocaine-esketamine were statistically significant but clinically modest, limiting their routine use.
- The treatment was safe without serious side effects, involving 304 patients, with 48% undergoing open surgery, and all received standard care including transversus abdominis plane blocks.