Accuracy of glomerular filtration rate estimation based on creatinine and cystatin C for monitoring moderate chronic kidney disease in adults: prospective, longitudinal cohort study - PubMed
7 hours ago
- #chronic kidney disease
- #biomarkers
- #glomerular filtration rate
- Study evaluates accuracy of GFR estimation using creatinine and cystatin C in monitoring moderate chronic kidney disease.
- Prospective, longitudinal cohort study with 1229 adults with moderate CKD (GFR 30-59 mL/min/1.73 m²).
- Dual biomarker equations (creatinine and cystatin C) showed better agreement with measured GFR changes than single biomarker equations.
- Median measured GFR decreased from 48.1 to 43.6 mL/min/1.73 m² over three years.
- All GFR equations had poor sensitivity (<54.1%) but good specificity (>90.4%) for identifying CKD progression.
- Underestimation of GFR reduction by estimated GFR requires further investigation.
- Increased use of combined biomarker equations could improve CKD monitoring and clinical care.