Aeroallergens in Atopic Dermatitis and Chronic Urticaria - PubMed
3 days ago
- #Chronic Urticaria
- #Atopic Dermatitis
- #Aeroallergens
- Aeroallergens are established triggers for allergic rhinitis and asthma but their role in skin diseases like atopic dermatitis (AD) and chronic urticaria (CU) is not fully understood.
- The molecular mechanisms involve epithelial barrier disruption, innate immune activation, and neuroimmune amplification, with pathways like PAR-2 and TLR signaling leading to an IL-31-driven itch-scratch cycle.
- Biologics targeting these pathways show potential in reshaping cytokine networks, and checkpoint inhibitors may offer durable remission.
- In CU, house dust mite sensitization is linked to basophil hyperreactivity and increased disease severity.
- Future research should focus on endotype-based patient stratification and assessing the impact of aeroallergen exposure on chronic skin disease progression.