Imaging endpoints in inflammatory bowel disease: current evidence and future directions for ultrasound and MRI - PubMed
2 hours ago
- #Medical Imaging
- #Clinical Trials
- #Inflammatory Bowel Disease
- Imaging endpoints like intestinal ultrasound (IUS) and MRI are crucial in IBD for assessing transmural inflammation and extraintestinal complications beyond endoscopy.
- Recent consensus statements support standardizing IUS and MRI as trial endpoints, including technical standards, definitions of response/remission, and the concept of transmural healing.
- A practical framework is proposed for integrating imaging into clinical trials, covering screening, monitoring, and evaluation, with emphasis on central reading and standardized data to reduce bias.
- Future directions include pragmatic evaluation in trials and routine care, cost-effectiveness analyses, and studies on whether imaging improves patient adherence compared to traditional pathways.