Proctocolectomy with permanent ileostomy is associated with improved transplant-free survival in patients with PSC - PubMed
5 hours ago
- #gut-liver axis
- #PSC
- #colectomy
- Proctocolectomy with permanent ileostomy improves transplant-free survival in PSC patients.
- Study analyzed data from the International PSC Registry (IPSCR) across multiple countries.
- Primary endpoint was liver transplantation (LT) or PSC-related death.
- Proctocolectomy with ileostomy showed significant reduction in risk (HR 0.41).
- Hemi- or subtotal colectomy had less pronounced effect (HR 0.81).
- No benefit observed for proctocolectomy with pouch (HR 1.00).
- Reduced risk mainly linked to lower rates of LT or death from liver failure.
- Findings support the gut-liver axis role in PSC pathophysiology.
- Results suggest surgical management of colonic disease may impact PSC prognosis.