The role of MyD88 in the nervous system: Neuronal functions, implications in neurological diseases, and therapeutic potential - PubMed
6 hours ago
- #MyD88
- #Neurodegenerative diseases
- #Neuroinflammation
- MyD88 is a key adaptor protein in Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling, playing a role in neuroimmune interactions and neuromodulation.
- MyD88 is expressed widely in the nervous system, influencing both glial cells and neuronal networks, with roles in neurodevelopment and neuroinflammation.
- The article reviews MyD88's involvement in brain injury, chronic pain, and neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS.
- Therapeutic approaches targeting MyD88-dependent pathways are discussed, emphasizing neuroprotective potential and the need for cell-selective therapies.
- The review advocates for more precise and translational MyD88-targeted interventions to improve treatment outcomes.