Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitors - PubMed
5 hours ago
- #morphogen signaling
- #neural development
- #single-cell analysis
- The study investigates the variability in how single neural progenitor cells respond to Sonic Hedgehog (Shh) signaling and their subsequent fate decisions.
- Using live imaging in zebrafish, researchers tracked Shh response and fate reporters in individual cells, revealing significant heterogeneity between Shh dynamics and fate outcomes.
- Motor neuron progenitors (pMNs) showed high variability in Shh responses, especially in the posterior neural tube where their dynamics resembled those of more ventrally fated lateral floor plate cells (LFPs).
- The findings suggest limits to the precision of morphogen-based genetic regulatory networks in predicting cell fate in small, dynamic cell populations during neural tube patterning.