Malic enzyme 1 contributes to tumorigenesis and lenvatinib resistance in hepatocellular carcinoma via FSP1-dependent ferroptosis evasion - PubMed
6 hours ago
- #Ferroptosis
- #Drug Resistance
- #Hepatocellular Carcinoma
- ME1 is significantly upregulated in hepatocellular carcinoma (HCC) tissues and linked to poor prognosis.
- ME1 promotes HCC cell viability in vitro and tumor growth in vivo, with knockout reducing tumor burden in mice.
- ME1 overexpression confers resistance to lenvatinib, a first-line HCC drug, while ME1 knockout restores sensitivity.
- ME1 regulates ferroptosis in HCC cells through NADPH production, activating the NADPH-FSP1-CoQH2 axis.
- FSP1 uses ubiquinol (CoQH2) as an antioxidant to inhibit lipid peroxide accumulation and prevent ferroptosis.