Neuronal TDP-43 regulates myelin formation via neurexin 1 mRNA stabilization - PubMed
6 hours ago
- #TDP-43
- #ALS/FTLD
- #myelin formation
- Neuronal TDP-43 regulates myelin formation by stabilizing neurexin 1 (NRXN1) mRNA.
- Neuron-specific TDP-43 knockout (TDP-43cKO) mice exhibited hypomyelination, which was restored by cytoplasmic TDP-43 or NRXN1b supplementation.
- TDP-43 stabilizes Nrxn1 mRNA by binding to its 3' untranslated region (3'UTR).
- TDP-43cKO mice showed impaired recognition memory, recoverable by NRXN1 supplementation in the hippocampus.
- The study highlights neuron-oligodendrocyte interactions mediated by TDP-43, relevant to ALS/FTLD disease mechanisms.