Circulating Liver-Derived and CD36+ Extracellular Vesicles Correlate With Ectopic Liver Fat and Markers of Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease and Decrease During Weig
6 hours ago
- #Biomarkers
- #Extracellular Vesicles
- #MASLD
- Circulating liver-derived (ASGR1+-EVs) and CD36+ extracellular vesicles (EVs) are studied as potential biomarkers for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
- Individuals with obesity and MASLD showed significantly higher levels of ASGR1+-EVs compared to lean individuals and higher CD36+-EVs compared to both obese and lean controls.
- During a weight loss intervention, levels of ASGR1+-EVs, CD36+-EVs, and ASGR1+CD36+-EVs decreased significantly in the MASLD group, starting as early as 1 month.
- CD36+-EV levels correlated with liver fat content, total body fat, and markers of liver fibrosis, suggesting their potential as non-invasive biomarkers for MASLD.
- This study is the first to report on circulating ASGR1+-EVs and CD36+-EVs in MASLD, expanding knowledge on EVs in disease development and their biomarker potential.