Proteomic Trajectories of Metabolic and Proteostatic Adaptation During Normothermic Liver Perfusion - PubMed
5 hours ago
- #liver transplantation
- #proteomics
- #biliary complications
- The study used proteomics to analyze liver grafts during normothermic machine perfusion (NMP) and reperfusion to understand molecular differences related to biliary complications after transplantation.
- Uncomplicated grafts showed glycolytic activation and reduced oxidative phosphorylation during NMP, while complicated grafts had blunted glycolysis and increased oxidative phosphorylation.
- At reperfusion, complicated grafts exhibited signs of endoplasmic reticulum stress and translational activation, whereas resilient grafts maintained proteasome-related protein turnover and hypoxia response.
- The findings suggest that proteomic signatures, including metabolic and proteostatic adaptations, could improve graft viability assessment beyond current biochemical criteria.