Mild hypothermia alleviates ferroptosis in kidney ischemia-reperfusion injury via the glycolysis-lactate-HMGB1 lactylation axis - PubMed
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- #Mild Hypothermia
- #Ferroptosis
- #Kidney IRI
- Mild hypothermia (MH) alleviates ferroptosis in kidney ischemia-reperfusion injury (IRI).
- MH preserves renal function, reduces oxidative stress, and inhibits ferroptosis markers like iron overload and lipid peroxidation.
- The protective mechanism involves suppression of the glycolysis-lactate-HMGB1 lactylation axis.
- HMGB1 lactylation and its cytoplasmic translocation are inhibited by MH.
- Interventions like Erastin (ferroptosis inducer) and CTPB (lactylation enhancer) reversed MH's protective effects.
- HMGB1 knockdown attenuated ferroptosis marker changes in OGD/R models.
- Glycolysis promoter Rotenone reversed MH-mediated suppression of lipid peroxidation and inflammatory cytokines.
- MH reduces inflammatory cytokine expression (IL-1β, IL-6, TNF-α) in kidney IRI.
- The study suggests MH as a potential therapeutic strategy for kidney IRI.