Ribonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules - PubMed
5 hours ago
- #aging
- #circular RNA
- #stress granule
- Ribonuclease κ (RNASEK) prevents age-dependent accumulation of circular RNAs (circRNAs) by promoting their degradation.
- RNASEK is downregulated during aging, leading to increased circRNA levels.
- RNASEK is necessary and sufficient for lifespan extension and healthspan maintenance in Caenorhabditis elegans.
- Mammalian RNASEK also degrades circRNAs and prevents premature aging in human cells and mice.
- CircRNAs localize within stress granules, where RNASEK collaborates with HSP90 to prevent toxic aggregation in aged organisms.
- RNASEK is identified as a conserved regulator of aging, offering a strategy to target circRNAs for mitigating age-associated diseases.