The Effects of Nitrate on Brown Fat Fraction and Activation in Older Adults With Type 2 Diabetes: A Randomised, Double-Blind and Placebo-Controlled Crossover Trial - PubMed
10 hours ago
- #Nitrate Supplementation
- #Brown Adipose Tissue
- #Type 2 Diabetes
- The study investigated the effects of nitrate supplementation from beetroot juice (BJ) on brown adipose tissue (BAT) fat fraction and activation in older adults with Type 2 Diabetes (T2DM).
- A double-blind, randomized, placebo-controlled crossover trial was conducted with 13 participants (HbA1c: 58 ± 13 mmol·mol-1, BMI: 29.1 ± 3.1 kg·m-2).
- Participants consumed 140 mL·day-1 of BJ (containing inorganic nitrate) or placebo for 14 days, with outcomes measured before and after the intervention.
- Magnetic resonance imaging (MRI) and infrared thermography (IRT) were used to assess BAT fat fraction and activation following a cooling protocol.
- Nitrate supplementation significantly increased plasma nitrate and nitrite levels but did not affect BAT fat fraction or activation.
- Cooling reduced mean skin temperature in both BJ and placebo groups, with respiratory exchange ratio (RER) indicating non-shivering thermogenesis.
- The study concluded that 14-day nitrate supplementation did not enhance BAT fat fraction or activation in older adults with T2DM.