Complement 5a receptor 2 attenuates diabetic kidney disease by promoting mitochondria-associated endoplasmic reticulum membrane formation mediated by PSS-MFN2 interaction - PubMed
6 hours ago
- #Mitochondria-Associated ER Membrane
- #Complement Receptor
- #Diabetic Kidney Disease
- C5aR2 expression increases in diabetic kidney disease (DKD) patients and correlates with disease severity.
- C5aR2 deficiency in diabetic mice worsens DKD, causing lipid accumulation and organelle dysfunction.
- C5aR2 activates c-FOS, upregulates phosphatidylserine synthase (PSS), and promotes PSS-MFN2 interaction.
- This interaction enhances mitochondria-associated ER membrane (MAM) formation and phosphatidylserine (PS) biosynthesis.
- C5aR2 agonist P59 improves DKD, PS homeostasis, and MAM formation, reversing lipid and organelle dysfunction.
- Single-cell RNA-seq shows P59 restores Pss expression in injured proximal tubular cells in mice.
- C5aR2 activation is highlighted as a promising therapeutic strategy for DKD.