HSD3B1 links ileal steroid metabolism to bile acid regulation in patients with prostate cancer - PubMed
4 hours ago
- #Androgen Deprivation Therapy
- #Prostate Cancer
- #Bile Acid Metabolism
- HSD3B1 connects intestinal steroid metabolism to bile acid regulation in prostate cancer patients.
- ADT leads to metabolic dysregulation, with HSD3B1 genotype affecting bile acid levels.
- HSD3B1 and SLC10A2 co-express in the ileum, regulated by LRH-1.
- LRH-1 inhibition disrupts bile acid transport and upregulates HSD11B2.
- The LRH-1/HSD3B1/SLC10A2 axis may be a target for therapy against ADT side effects.