Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation - PubMed
4 hours ago
- #LRRK2
- #alpha-synuclein
- #autophagy
- Knockout of phosphatase PPM1H disrupts autophagosome transport in axons.
- This disruption leads to impaired degradation of axonal alpha-synuclein.
- Defective autophagy correlates with increased alpha-synuclein aggregation.
- The effect is dependent on LRRK2 kinase activity and gene-dose-related.
- LRRK2-RAB axis is identified as a key driver in Parkinson's disease pathophysiology.