Characterization of lung microbiota in pneumonia: a pilot study in ICU and non-ICU patients - PubMed
5 hours ago
- #pneumonia
- #ICU
- #lung microbiota
- Objective: Identify differences in lung microbiota based on clinical severity, age, and gender in pneumonia patients vs. controls.
- Study Design: Pilot study with 33 participants (11 ICU, 11 non-ICU pneumonia patients, 11 cadaver controls).
- Key Findings: Bacteroidota and Verrucomicrobiota phyla were more abundant in older (≥65 years) ICU/non-ICU patients.
- Massilia timonae showed lower relative abundance in pneumonia cases, potentially increasing infection susceptibility.
- Higher microbiota diversity was observed in older patients.
- Conclusion: Lung microbiota alterations in pneumonia patients, especially older individuals, may inform pathophysiology and dysbiosis insights.