Monkeypox virus protein OPG188 antagonizes cGAS-STING antiviral signaling pathway to mediate immune evasion - PubMed
6 hours ago
- #cGAS-STING pathway
- #Immune evasion
- #Monkeypox virus
- Monkeypox virus (MPXV) protein OPG188 antagonizes the cGAS-STING antiviral signaling pathway to mediate immune evasion.
- Three MPXV genes (OPG147, OPG188, OPG200) suppress cGAS-STING pathway activation.
- The N-terminal domain of Poxin (encoded by OPG188) cleaves 2'3'-cGAMP, a cyclic dinucleotide second messenger.
- Key amino acid residues (H15, K140, R182, I79) in Poxin are essential for antagonizing cGAS-STING signaling.
- Two small molecules (NAD+ and Theaflavin-3'-gallate) were identified as inhibitors of Poxin's cGAMP-degrading activity.
- These findings highlight potential therapeutic candidates for anti-MPXV treatments.