Arginine dependency in omental metastasis of epithelial ovarian cancer reveals a therapeutic vulnerability - PubMed
8 hours ago
- #Metastasis
- #Epithelial Ovarian Cancer
- #Arginine Metabolism
- Arginine dependency in omental metastasis of epithelial ovarian cancer (EOC) highlights a metabolic vulnerability.
- Defective endogenous arginine synthesis in EOC leads to reliance on exogenous uptake for tumor growth and metastasis.
- Dietary arginine deprivation suppresses tumor growth and metastasis, while supplementation enhances proliferation, invasion, and migration.
- Increased arginine binds to DDX3X, promoting its nuclear retention and transcription of DNA damage response (DDR) genes.
- Arginine facilitates DDR via the ATM/CHK2/P53 axis, aiding cancer cell survival under metastatic stress.
- Arginine restriction or pharmacological inhibition of DDX3X effectively suppresses primary tumor growth and omental metastasis in mouse models.