Pulmonary Vein Isolation in Early-Onset Atrial Fibrillation (≤50 Years): A Multicenter Comparison of Pulsed-Field Ablation versus Thermal Energy Sources - PubMed
6 hours ago
- #Pulsed-Field Ablation
- #Young Patients
- #Atrial Fibrillation Ablation
- Pulsed-field ablation (PFA), cryoballoon ablation (Cryo), and radiofrequency ablation (RFA) were compared in a multicenter study of young patients (≤50 years) with early-onset atrial fibrillation undergoing first-time pulmonary vein isolation.
- Procedure durations and left atrial dwell times were significantly shorter for PFA (59 min, 36 min) and Cryo (63 min, 44 min) compared to RFA (94 min, 76 min).
- Acute PVI success was achieved in all patients, with major complications low overall (0.8%), including one phrenic nerve palsy with Cryo and two tamponades with RFA.
- At 1-year follow-up, recurrence-free survival rates were 69% for PFA, 61% for Cryo, and 73% for RFA, with no statistically significant difference among groups.
- The study concluded that PFA demonstrated favorable procedural efficiency, safety, and effectiveness, supporting its potential for treating early-onset AF in young patients, though further research is needed.