Mitochondrial NAD kinase Pos5 is required for CoQ biosynthesis in yeasts - PubMed
6 hours ago
- #Coenzyme Q biosynthesis
- #Mitochondrial NAD kinase
- #Yeast genetics
- Mitochondrial NAD kinase Pos5 is essential for CoQ biosynthesis in yeasts.
- Deletion of Pos5 reduces CoQ10 to 0.2-fold of wild-type levels in Schizosaccharomyces pombe.
- Functional conservation shown as Saccharomyces cerevisiae Pos5 restores CoQ in S. pombe Δpos5.
- Δpos5 and ΔScpos5 strains show CoQ-deficient phenotypes like growth failure on non-fermentable carbon sources.
- Pos5 likely supports an earlier step in CoQ biosynthesis, possibly via NADPH for enzymes like Coq6.