Predictors of Acute Exacerbations in COPD: A Systematic Review - PubMed
4 hours ago
- #AECOPD predictors
- #COPD
- #systematic review
- COPD is characterized by acute exacerbations (AECOPD), which drive disease progression and burden.
- This systematic review identifies clinical predictors of moderate and severe AECOPD and relapse within 28 days of a previous AECOPD.
- 61 distinct predictors were assessed, with 37 showing statistical significance (P < 0.05).
- Key predictors include age, AECOPD history, fibrinogen levels, FEV1, bronchodilator response, SGRQ-C scores, and COPD GOLD classification (2-4, B-D).
- Only 11 out of 30 studies had a low risk of bias.
- Most promising predictors: history of ≥1 AECOPD, higher SGRQ-C scores, elevated fibrinogen, and worse COPD GOLD classification.
- Future research should focus on standardizing AECOPD definitions and predictor cut-off values.
- Combining diverse predictor domains into composite measures may enhance predictive accuracy.