Staphylococcal Superantigens-specific IgE Reveals Functional Superantigen Production Beyond Staphylococcus aureus in CRSwNP - PubMed
10 hours ago
- #Staphylococcal superantigen
- #CRSwNP
- #Type 2 inflammation
- Staphylococcal superantigen-specific IgE (SAg-IgE) is linked to disease severity in type 2 chronic rhinosinusitis with nasal polyps (CRSwNP).
- Even in patients with culture-negative Staphylococcus aureus (S. aureus), SAg-IgE is detected, suggesting other sources of superantigens (SAgs).
- Metagenomic sequencing in SAg-IgE-positive CRSwNP patients identified higher abundances of Staphylococcus epidermidis, S. aureus, Lysinibacillus xylanilyticus, and Staphylococcus capitis (S. capitis).
- S. capitis was found to carry SEA and SEC genes and secreted functional SAgs, triggering T-cell receptor (TCR) expansion and type 2 inflammation via IL-33.
- SAg-IgE positivity reliably indicates bacterial colonization and SAg exposure in CRSwNP, independent of culturable bacterial load.