Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma - PubMed
4 days ago
- #Skin Barrier Dysfunction
- #Staphylococcus aureus
- #Cutaneous T-cell Lymphoma
- Staphylococcus aureus (S. aureus) and its enterotoxins (SEs) contribute to skin barrier damage in Cutaneous T-cell Lymphoma (CTCL) by activating T cells.
- Activated T cells release cytokines (IL-4, IL-13, IL-22, OSM) that repress keratinocyte proteins like filaggrin and loricrin via JAK pathways.
- In vivo studies show antibiotic treatment can restore filaggrin and loricrin expression, reducing skin barrier damage in CTCL patients colonized by SE-producing S. aureus.
- The findings suggest microbial-immune interactions worsen CTCL skin pathology, supporting adjunctive therapies targeting S. aureus colonization.