ATP5A1 succinylation as a key driver for the transition of myocardial ischemia to development of heart failure - PubMed
6 hours ago
- #heart failure
- #ischemic cardiomyopathy
- #ATP5A1 succinylation
- Elevated succinate levels correlate with heart failure (HF) risk and progression in coronary artery disease patients.
- Succinate-driven succinylation of ATP5A1 at K531 impairs ATP synthase activity and assembly, promoting mitochondrial dysfunction and cardiomyocyte death.
- Targeting ATP5A1 desuccinylation, via Sirtuin 5 and carnitine palmitoyltransferase 1A, offers a therapeutic strategy against ischemic injury and HF development.