Arginine methylation-dependent stabilization of SUV39H1 promotes breast cancer growth - PubMed
4 days ago
- #breast cancer
- #PRMT1
- #SUV39H1
- SUV39H1, responsible for H3K9me3 marks, is frequently dysregulated in cancers.
- PRMT1 interacts with and dimethylates SUV39H1 at arginine 378 (R378).
- PKC signaling-mediated phosphorylation at S391 enhances PRMT1-SUV39H1 interaction.
- PRMT1 binding blocks MDM2-mediated ubiquitination of SUV39H1, stabilizing it.
- Methylated SUV39H1 shows enhanced H3K9me3 activity and promotes tumor growth.
- A peptide (TAT-SUV-peptide) disrupts PRMT1-SUV39H1 interaction, reducing methylation.
- TAT-SUV-peptide administration suppresses mammary tumor growth effectively.