Extracellular Vesicles From Mesenchymal Stromal Cells Drive Muscle and Neuronal Regeneration Through TNFα Modulation - PubMed
14 hours ago
- #regenerative medicine
- #TNFα modulation
- #extracellular vesicles
- Extracellular vesicles (EVs) from mesenchymal stromal cells promote muscle and neuronal regeneration by modulating TNFα.
- EVs protect human muscle precursor cells from death after damage, reducing cCAS3 and enhancing cell proliferation.
- In neuroinflammation models, EVs inhibit TNFα and support neural axon sprouting, showing potential for tissue regeneration.
- The study uses 3D multicellular models, including human muscle decellularized tissue and organotypic spinal cord from rat fetuses.
- EVs demonstrate therapeutic potential for muscle defects caused by accidents, tumor resection, and congenital malformations.
- A patent application related to the findings has been filed, with some authors having ties to EXO Biologics.