VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement - PubMed
10 hours ago
- #unconventional secretion
- #tumor microenvironment
- #VAMP7
- VAMP7-dependent late endosomal secretion involves unconventional secretion of ER and mitochondrial proteins.
- VAMP7 knockout cells show impaired secretion of ER- and mitochondrial-derived proteins, leading to organellar stress.
- Pharmacological induction of organellar stress enhances VAMP7-dependent secretion.
- In a glioblastoma model, VAMP7 knockout leads to more necrotic tumors with reduced macrophage infiltration.
- Late endosomal secretion acts as an organelle quality-control and stress-communication mechanism, relevant in cancer.