Single-cell transcriptomics reveals immune landscape dynamics in metastatic hormone receptor-positive breast cancer treated with abemaciclib and endocrine therapy - PubMed
3 hours ago
- #immune landscape
- #single-cell transcriptomics
- #breast cancer
- CDK4/6 inhibitors combined with endocrine therapy are standard first-line treatment for advanced ER+/HER2- breast cancer.
- Abemaciclib and endocrine therapy modulate the tumor immune microenvironment, including effects on T cells and myeloid cells.
- Single-cell RNA-seq of 13 matched-pair biopsies shows downregulation of interferon-response genes in T cell populations.
- Treatment upregulates antigen presentation genes in tumor-associated macrophages and dendritic cells.
- Decrease in TREM2+ tumor-associated macrophages post-treatment correlates with improved overall survival in breast cancer patients.