CRP Deficiency Rescues Periodontitis-Induced Hippocampal Neurogenesis Impairment by Suppressing OPC-Derived BMP4 Signaling in Rats - PubMed
6 hours ago
- #CRP-BMP4 axis
- #neurogenesis
- #periodontitis
- Chronic periodontitis (PD) in rats leads to anxiety/depression-like behaviors and impaired hippocampal neurogenesis.
- Elevated hippocampal levels of C-reactive protein (CRP) are associated with these impairments, with CRP predominantly derived from the periphery.
- Knockout of Crp attenuates PD-induced hippocampal impairments by downregulating bone morphogenetic protein 4 (Bmp4).
- Single-nucleus RNA sequencing reveals that hippocampal Bmp4 is mainly expressed by oligodendrocyte precursor cells (OPCs).
- CRP deficiency enhances the functional resilience of OPCs.
- Inhibition of the CRP-BMP4 axis restores neuronal differentiation suppressed by PD and alleviates behavioral abnormalities.
- The findings suggest the CRP-BMP4 axis as a potential therapeutic target for preventing PD-related neurological complications.