Targeting BRD2 and BRD4 inhibit the growth of KSHV-infected immortalized endothelial cells through suppression of LANA translation - PubMed
4 hours ago
- #KSHV
- #BET inhibitors
- #LANA translation
- BRD2 and BRD4 targeting via PROTAC degraders MZ-1 and SIM-1 inhibits growth in KSHV-infected immortalized endothelial cells.
- The inhibitory mechanism involves suppression of LANA translation through increased eIF2α phosphorylation.
- RNAi-mediated silencing of BRD2 or BRD4 similarly suppresses LANA, unlike BET inhibitors such as (+)-JQ1.
- Proteomic analysis reveals unique protein changes in cells treated with MZ-1 and SIM-1 compared to (+)-JQ1.
- This strategy offers potential for improving therapies against KSHV-related cancers like Kaposi's sarcoma.