Minor neuropsychological deficits and stage 2 of Alzheimer's disease - PubMed
3 hours ago
- #Alzheimer's disease
- #cognitive impairment
- #preclinical stage
- The study emphasizes the significance of subtle symptoms like subjective cognitive decline (SCD) and minor neuropsychological deficits (MNPD) for risk stratification in preclinical Alzheimer's disease (AD).
- Data from cognitively normal individuals across three cohort studies (N=13,192) showed increased risk for mild cognitive impairment (MCI) and dementia in SCD-/MNPD+, SCD+/MNPD-, and SCD+/MNPD+ groups, including those with amyloid positivity.
- Combining SCD and MNPD (SCD+/MNPD+) triples the positive predictive value of amyloid testing for 5-year MCI prediction and reduces required sample sizes for clinical trials to one-fourth, enhancing trial designs and early treatment identification.