Neuroinflammatory mechanisms and pharmacological advances in autism spectrum disorder: from inflammatory pathways to targeted interventions - PubMed
4 hours ago
- #neuroinflammation
- #pharmacological-interventions
- #autism-spectrum-disorder
- ASD lacks reliable biomarkers and mechanism-based treatments; neuroinflammation is linked to its risk, symptoms, and course.
- The PC-ICAM model outlines a peripheral-to-central inflammatory cascade, from maternal immune activation to CNS amplification.
- Peripheral signals affect the brain via BBB vulnerability, extracellular vesicles, and neuro-immune pathways.
- Inflammatory pathways like NF-κB, JAK/STAT, and NLRP3 converge with glial activation and synaptic disturbances.
- Targeted interventions include IL-6/IL-17 blockers, inflammasome inhibitors, glial modulators, and BBB stabilizers.
- Precision treatment requires multi-node, mechanism-matched strategies along the inflammatory cascade.