Vitamin B3 derivatives support pancreatic cancer cell survival and chemotherapy resistance - PubMed
11 hours ago
- #Pancreatic Cancer
- #Chemotherapy Resistance
- #NAD+ Precursors
- Vitamin B3 derivatives (NAM, NR, NMN) are marketed as nutraceuticals with potential health benefits.
- NAD+ precursors, including NMN, enhance chemotherapy resistance in pancreatic ductal adenocarcinoma (PDAC).
- NMN showed the strongest protective effect, promoting mitochondrial function and reducing oxidative stress in cancer cells.
- NAD+ supplements support cancer cell survival by suppressing DNA damage and apoptosis during chemotherapy.
- In vivo studies confirmed that NAM and NMN supplementation leads to chemotherapy resistance in PDAC models.
- The findings suggest caution in using NAD+-boosting supplements during cancer treatment, as they may compromise therapy efficacy.