Mitochondria-associated endoplasmic reticulum membranes as aging-sensitive signaling hubs in degenerative musculoskeletal diseases - PubMed
6 hours ago
- #Mitochondria-associated membranes
- #Musculoskeletal aging
- #Organelle crosstalk
- Mitochondria-associated endoplasmic reticulum membranes (MAMs) serve as key signaling hubs sensitive to aging in degenerative musculoskeletal diseases (DMDs).
- Aging disrupts MAMs integrity, leading to mitochondrial dysfunction, oxidative stress, and inflammatory responses in musculoskeletal tissues.
- MAMs coordinate critical processes like calcium signaling, lipid metabolism, autophagy, and cell death, which are implicated in DMDs such as osteoarthritis and osteoporosis.
- The review identifies shared and tissue-specific mechanisms of MAMs dysregulation in driving musculoskeletal degeneration with age.